Pamukkale (Cotton Palace) is made up of solidified white calcite travertines (terraces) with cascading thermal pools. Hieropolis was built on top of Pamukkale in the early 2nd century BC. Denizli airport (DNZ) is located closest to the attraction with daily nonstop flights from Istanbul.
Award booking flights to Denizli (DNZ)
I recommend using Aeroplan miles to book business class flights to Denizli airport and plan for a stopover in Istanbul for 5K additional miles as needed (see image below).
Turkish Miles & Smiles WILL NOT let you combine business and economy classes together for connections (see image below) and it will show business class as “Full”.
Pamukkale Accommodation
Pamukkale has no properties to book with points (except for a Mr & Mrs Smith with Hyatt), but the it is easy to find reasonably priced accommodations with over 1K reviews on Booking.com (link).
Pamukkale Scenery
Conclusion
Pamukkale can be explored in a day after taking a nonstop flight from Istanbul, and Turkish Airlines flights can be booked with Aeroplan points or LifeMiles.